Photodelivery of ß-phenylethylamines.

ABSTRACT

We have developed the first photodonors for the trace amino neurotransmitters, ß-phenylethylamine (DPSY1) and ß-methylphenylethylamine (DPSY2). Our photodonors react rapidly with photosensitized singlet dioxygen (1O2) to yield the amines. The photodelivery of ß-phenylethylamine into aqueous solutions by employing liposome scaffolds is successfully demonstrated.