Effect of sex hormones on coronavirus disease 2019: an analysis of 5,061 laboratory-confirmed cases in South Korea.
Menopause
; 27(12): 1376-1381, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-33003134
ABSTRACT
OBJECTIVE:
To evaluate the effect of female sex hormones on the clinical outcomes of coronavirus disease 2019 patients using national claims data.METHODS:
This retrospective cohort study used the Health Insurance Review and Assessment data of 5,061 adult patients with laboratory-confirmed coronavirus disease 2019 in South Korea from January 20 to April 8, 2020. To evaluate the effect of hormone therapy on clinical outcomes among women, subgroup analyses using age-matched case-control data were performed.RESULTS:
Coronavirus disease 2019 was most prevalent in women in the 20-39 years age group (1,250 [44.14%]). Men were more likely to receive oxygen therapy (144 [6.46%] vs 131 [4.63%], Pâ=â0.004), be admitted to the intensive care unit (60 [2.69%] vs 53 [1.87%], Pâ=â0.049), and have a longer length of stay after admission to the intensive care unit (19.70 ± 11.80 vs 14.75â±â9.23, Pâ=â0.016). However, there was no significant difference in the mortality rate (men vs women 42 [1.88%] vs 42 [1.48%], Pâ=â0.267). In the multivariable Cox analysis, older age and underlying comorbidities, but not sex, were independent risk factors for mortality. Hormone therapy was not significantly associated with clinical outcomes.CONCLUSIONS:
This study, using nationwide data, suggests that female sex hormones are not associated with the morbidity and clinical outcomes of coronavirus disease 2019 in South Korea.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônios Esteroides Gonadais
/
Teste para COVID-19
/
COVID-19
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article