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Antidepressant Medications and Weight Change: A Narrative Review.
Gill, Hartej; Gill, Barjot; El-Halabi, Sabine; Chen-Li, David; Lipsitz, Orly; Rosenblat, Joshua Daniel; Van Rheenen, Tamsyn E; Rodrigues, Nelson B; Mansur, Rodrigo B; Majeed, Amna; Lui, Leanna M W; Nasri, Flora; Lee, Yena; Mcintyre, Roger S.
Afiliação
  • Gill H; Mood Disorders Psychopharmacology Unit, Poul Hansen Family Centre for Depression, University Health Network, Toronto, Ontario, Canada.
  • Gill B; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
  • El-Halabi S; Mood Disorders Psychopharmacology Unit, Poul Hansen Family Centre for Depression, University Health Network, Toronto, Ontario, Canada.
  • Chen-Li D; Mood Disorders Psychopharmacology Unit, Poul Hansen Family Centre for Depression, University Health Network, Toronto, Ontario, Canada.
  • Lipsitz O; Mood Disorders Psychopharmacology Unit, Poul Hansen Family Centre for Depression, University Health Network, Toronto, Ontario, Canada.
  • Rosenblat JD; Mood Disorders Psychopharmacology Unit, Poul Hansen Family Centre for Depression, University Health Network, Toronto, Ontario, Canada.
  • Van Rheenen TE; Mood Disorders Psychopharmacology Unit, Poul Hansen Family Centre for Depression, University Health Network, Toronto, Ontario, Canada.
  • Rodrigues NB; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
  • Mansur RB; Brain and Cognition Discovery Foundation, Toronto, Ontario, Canada.
  • Majeed A; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.
  • Lui LMW; Centre for Mental Health, Faculty of Health, Arts and Design, School of Health Sciences, Swinburne University, Melbourne, Victoria, Australia.
  • Nasri F; Mood Disorders Psychopharmacology Unit, Poul Hansen Family Centre for Depression, University Health Network, Toronto, Ontario, Canada.
  • Lee Y; Mood Disorders Psychopharmacology Unit, Poul Hansen Family Centre for Depression, University Health Network, Toronto, Ontario, Canada.
  • Mcintyre RS; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Obesity (Silver Spring) ; 28(11): 2064-2072, 2020 11.
Article em En | MEDLINE | ID: mdl-33022115
Antidepressant medications are the first-line treatment option for moderate to severe major depressive disorder. However, most antidepressants have numerous documented adverse events, including cardiometabolic effects and weight gain, which are major public health concerns. Antidepressant agents provide varying risk of associated weight gain, including significant within-class differences. Some agents, such as mirtazapine, show significant levels of weight gain, while others, such as bupropion, demonstrate weight-loss effects. Current findings suggest the role of histamine and serotonin off-target appetite-promoting pathways in adverse weight-gain effects. Therefore, controlling for undesired weight effects is an important consideration for the selection of antidepressants.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aumento de Peso / Antidepressivos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aumento de Peso / Antidepressivos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article