Guanidinoacetic acid deficiency: a new entity in clinical medicine?
Int J Med Sci
; 17(16): 2544-2550, 2020.
Article
em En
| MEDLINE
| ID: mdl-33029096
ABSTRACT
Guanidinoacetic acid (GAA, also known as glycocyamine or betacyamine) is a naturally-occurring derivative of glycine and a direct metabolic precursor of creatine, a key player in high-phosphate cellular bioenergetics. GAA is found in human serum and urine, with circulating GAA likely reflects an equilibrium between its endogenous production and utilization/excretion. GAA deficiency (as indicated by low serum GAA) has been reported in various conditions yet this intriguing clinical entity appears to be poorly characterized as yet, either as a primary deficit or a sequel of secondary disease. This minireview article summarizes the inherited and acquired disorders with apparent GAA deficiency and discusses a possible relevance of GAA shortfall in clinical medicine.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicina
/
Doenças Metabólicas
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article