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CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway.
Deleye, Yann; Cotte, Alexia Karen; Hannou, Sarah Anissa; Hennuyer, Nathalie; Bernard, Lucie; Derudas, Bruno; Caron, Sandrine; Legry, Vanessa; Vallez, Emmanuelle; Dorchies, Emilie; Martin, Nathalie; Lancel, Steve; Annicotte, Jean Sébastien; Bantubungi, Kadiombo; Pourtier, Albin; Raverdy, Violeta; Pattou, François; Lefebvre, Philippe; Abbadie, Corinne; Staels, Bart; Haas, Joel T; Paumelle, Réjane.
Afiliação
  • Deleye Y; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.
  • Cotte AK; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.
  • Hannou SA; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.
  • Hennuyer N; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.
  • Bernard L; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.
  • Derudas B; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.
  • Caron S; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.
  • Legry V; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.
  • Vallez E; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.
  • Dorchies E; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.
  • Martin N; Univ. Lille, CNRSInstitut Pasteur de Lille, UMR 8161-M3T-Mechanisms of Tumorigenesis and Target Therapies, Lille, France.
  • Lancel S; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.
  • Annicotte JS; Univ. Lille, CNRSCHU Lille, Institut Pasteur de Lille, UMR 8199-EGID, Lille, France.
  • Bantubungi K; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.
  • Pourtier A; Univ. Lille, CNRSInstitut Pasteur de Lille, UMR 8161-M3T-Mechanisms of Tumorigenesis and Target Therapies, Lille, France.
  • Raverdy V; Univ. Lille, Inserm, CHU Lille, UMR 1190-EGID, Lille, France.
  • Pattou F; Univ. Lille, Inserm, CHU Lille, UMR 1190-EGID, Lille, France.
  • Lefebvre P; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.
  • Abbadie C; Univ. Lille, CNRSInstitut Pasteur de Lille, UMR 8161-M3T-Mechanisms of Tumorigenesis and Target Therapies, Lille, France.
  • Staels B; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.
  • Haas JT; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.
  • Paumelle R; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France. Electronic address: rejane.lestrelin@univ-lille.fr.
J Biol Chem ; 295(50): 17310-17322, 2020 12 11.
Article em En | MEDLINE | ID: mdl-33037071
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mitocôndrias Hepáticas / Transdução de Sinais / Inibidor p16 de Quinase Dependente de Ciclina / PPAR alfa / Proteínas Quinases Ativadas por AMP / Ácidos Graxos / Sirtuína 1 / Fígado Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mitocôndrias Hepáticas / Transdução de Sinais / Inibidor p16 de Quinase Dependente de Ciclina / PPAR alfa / Proteínas Quinases Ativadas por AMP / Ácidos Graxos / Sirtuína 1 / Fígado Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article