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Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor Thr701 phosphorylation.
Gaviraghi, Marco; Rabellino, Andrea; Andolfo, Annapaola; Brand, Matthias; Brombin, Chiara; Bagnato, Paola; De Feudis, Giuseppina; Raimondi, Andrea; Locatelli, Alberta; Tosoni, Daniela; Mazza, Davide; Gianni, Luca; Tonon, Giovanni; Yarden, Yosef; Tacchetti, Carlo; Daniele, Tiziana.
Afiliação
  • Gaviraghi M; Division of Experimental Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 60, 20132, Milan, Italy.
  • Rabellino A; Department of Experimental Medicine, University of Genoa, via De Toni 14, 16132, Genoa, Italy.
  • Andolfo A; QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4029, Australia.
  • Brand M; Protein Microsequencing Facility, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 60, 20132, Milan, Italy.
  • Brombin C; Experimental Imaging Centre, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 58, 20132, Milan, Italy.
  • Bagnato P; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090, Vienna, Austria.
  • De Feudis G; University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, via Olgettina 58, 20132, Milan, Italy.
  • Raimondi A; Department of Experimental Medicine, University of Genoa, via De Toni 14, 16132, Genoa, Italy.
  • Locatelli A; Experimental Imaging Centre, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 58, 20132, Milan, Italy.
  • Tosoni D; Experimental Imaging Centre, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 58, 20132, Milan, Italy.
  • Mazza D; Department of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 60, 20132, Milan, Italy.
  • Gianni L; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, 20100, Milan, Italy.
  • Tonon G; Experimental Imaging Centre, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 58, 20132, Milan, Italy.
  • Yarden Y; Department of Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 60, 20132, Milan, Italy.
  • Tacchetti C; Division of Experimental Oncology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 60, 20132, Milan, Italy.
  • Daniele T; Center for Translational Genomics and Bioinformatics, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, via Olgettina 60, 20132, Milan, Italy.
Sci Rep ; 10(1): 16906, 2020 10 09.
Article em En | MEDLINE | ID: mdl-33037285
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosforilação / Transdução de Sinais / Receptores Proteína Tirosina Quinases / Receptor ErbB-2 / Citostáticos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosforilação / Transdução de Sinais / Receptores Proteína Tirosina Quinases / Receptor ErbB-2 / Citostáticos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article