Intramuscular accumulation of pentadecanoic acid activates AKT1 to phosphorylate NCOR1 and triggers FOXM1-mediated apoptosis in the pathogenesis of sarcopenia.

Chen, Fa-Xiu; Du, Ning; Hu, Jian; Ning, Fang; Mei, Xun; Li, Qiang; Peng, Le

Chen, Fa-Xiu; Du, Ning; Hu, Jian; Ning, Fang; Mei, Xun; Li, Qiang; Peng, Le.

Afiliação

Chen FX; Department of Geriatrics, Jiangxi Provincial People's Hospital Affiliated to Nanchang University Nanchang 330006, Jiangxi, China.
Du N; Department of Geriatrics, Jiangxi Provincial People's Hospital Affiliated to Nanchang University Nanchang 330006, Jiangxi, China.
Hu J; Department of Geriatrics, Jiangxi Provincial People's Hospital Affiliated to Nanchang University Nanchang 330006, Jiangxi, China.
Ning F; Department of Geriatrics, Jiangxi Provincial People's Hospital Affiliated to Nanchang University Nanchang 330006, Jiangxi, China.
Mei X; Department of Geriatrics, Jiangxi Provincial People's Hospital Affiliated to Nanchang University Nanchang 330006, Jiangxi, China.
Li Q; Department of Geriatrics, Jiangxi Provincial People's Hospital Affiliated to Nanchang University Nanchang 330006, Jiangxi, China.
Peng L; Department of Geriatrics, Jiangxi Provincial People's Hospital Affiliated to Nanchang University Nanchang 330006, Jiangxi, China.

Am J Transl Res ; 12(9): 5064-5079, 2020.

Article em En | MEDLINE | ID: mdl-33042406

Palavras-chave

AKT1; FOXM1; NCOR1; Sarcopenia; apoptosis; pentadecanoic acid

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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