Enantioselective Enzymatic Reduction of Acrylic Acids.
Org Lett
; 22(21): 8320-8325, 2020 11 06.
Article
em En
| MEDLINE
| ID: mdl-33048553
ABSTRACT
An ene-reductase (ERED 36) with broad substrate specificity was identified, and optimization studies led to the development of an enzymatic protocol for the reduction of α,ß-unsaturated acids under mild, aqueous conditions. The substrate scope includes aromatic- and aliphatic-substituted acrylic acids, as well as cyclic α,ß-substituted acrylic acids, yielding chiral α-substituted acids with exquisite levels of enantioselectivity (>99% ee).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxirredutases
/
Acrilatos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article