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NLRP3-dependent microglial training impaired the clearance of amyloid-beta and aggravated the cognitive decline in Alzheimer's disease.
He, Xiao-Fei; Xu, Jing-Hui; Li, Ge; Li, Ming-Yue; Li, Li-Li; Pei, Zhong; Zhang, Li-Ying; Hu, Xi-Quan.
Afiliação
  • He XF; Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, 510630, Guangzhou, Guangdong, China.
  • Xu JH; Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, 510630, Guangzhou, Guangdong, China.
  • Li G; The Eighth Affiliated Hospital, Sun Yat-sen University, 518000, Shenzhen, Guangdong, China.
  • Li MY; Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, 510663, Guangzhou, Guangdong, China.
  • Li LL; Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, 510630, Guangzhou, Guangdong, China.
  • Pei Z; Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, 510630, Guangzhou, Guangdong, China.
  • Zhang LY; Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, The First Affiliated Hospital, Sun Yat-sen University, 510080, Guangzhou, Guangdong, China.
  • Hu XQ; Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, 510630, Guangzhou, Guangdong, China. zhangliying_good@126.com.
Cell Death Dis ; 11(10): 849, 2020 10 13.
Article em En | MEDLINE | ID: mdl-33051464
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Microglia / Doença de Alzheimer / Disfunção Cognitiva / Proteína 3 que Contém Domínio de Pirina da Família NLR Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Microglia / Doença de Alzheimer / Disfunção Cognitiva / Proteína 3 que Contém Domínio de Pirina da Família NLR Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article