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Repeatability of Phase-Resolved Functional Lung (PREFUL)-MRI Ventilation and Perfusion Parameters in Healthy Subjects and COPD Patients.
Pöhler, Gesa H; Klimes, Filip; Behrendt, Lea; Voskrebenzev, Andreas; Gonzalez, Cristian Crisosto; Wacker, Frank; Hohlfeld, Jens M; Vogel-Claussen, Jens.
Afiliação
  • Pöhler GH; Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
  • Klimes F; Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.
  • Behrendt L; Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
  • Voskrebenzev A; Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.
  • Gonzalez CC; Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
  • Wacker F; Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.
  • Hohlfeld JM; Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
  • Vogel-Claussen J; Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.
J Magn Reson Imaging ; 53(3): 915-927, 2021 03.
Article em En | MEDLINE | ID: mdl-33058351
ABSTRACT

BACKGROUND:

Free-breathing phase-resolved functional lung (PREFUL)-MRI may be useful for treatment monitoring in chronic obstructive pulmonary disease (COPD) patients with dyspnea. PREFUL test-retest reliability is essential for clinical application.

PURPOSE:

To measure the repeatability of PREFUL-MRI ventilation (V) and perfusion (Q) parameters. STUDY TYPE Retrospective and prospective. POPULATION A total of 28 COPD patients and 57 healthy subjects. FIELD STRENGTH/SEQUENCE 1.5T MRI/2D spoiled gradient echo imaging. ASSESSMENT V and Q lung parameter maps based on three coronal slices were obtained at baseline and after 14 days (COPD patients) or after a short pause outside the scanner (healthy subjects). Regional ventilation (RVent) and imaging flow volume loops by cross-correlation (ccVent) were quantified. Q was normalized to the signal of the main pulmonary artery (QN ) and quantified (QQuant ). Pulmonary pulse wave transit time (pPTT), voxel-by-voxel (regional), and whole lung (global) ventilation defect percentage based on RVent (VDPRVent ) and ccVent (VDPccVent ), perfusion defect percentage (QDP), and ventilation/perfusion match based on RVent (VQMRVent ) and ccVent (VQMccVent ) were calculated. STATISTICAL TESTS Regional V and Q were analyzed globally for each subject. Each parameter's median of scans 1 and 2 were assessed by Wilcoxon sign rank test. A parameter's repeatability was analyzed by Bland-Altman analyses, coefficients of variation, intraclass correlation coefficients (ICC), and power calculations. The regional voxel repeatability was examined by calculating the Sørensen-Dice coefficient.

RESULTS:

There was no bias and no significant differences between the first and second MRI for any parameters (P > 0.05). Coefficient of variation ranged from 2.26% (ccVent) to 19.31% (QDP), ICC from 0.93 (QDP) to 0.60 (pPTT), the smallest detectable difference was 0.002 ccVent. Regional comparison showed the highest overlap (84%) in VDPRVent in healthy voxels and the lowest (53%) in VDPccVent defect voxels. DATA

CONCLUSION:

V and Q PREFUL-MRI parameters were repeatable over two scan sessions in both healthy controls and COPD patients. LEVEL OF EVIDENCE 2 TECHNICAL EFFICACY STAGE 2.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença Pulmonar Obstrutiva Crônica / Pulmão Tipo de estudo: Observational_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença Pulmonar Obstrutiva Crônica / Pulmão Tipo de estudo: Observational_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article