New thiazolopyrimidine as anticancer agents: Synthesis, biological evaluation, DNA binding, molecular modeling and ADMET study.

Al-Rashood, Sara T; Elshahawy, Shymaa S; El-Qaias, Asmaa M; El-Behedy, Dina S; Hassanin, Alshaimaa A; El-Sayed, Selwan M; El-Messery, Shahenda M; Shaldam, Moataz A; Hassan, Ghada S

Al-Rashood, Sara T; Elshahawy, Shymaa S; El-Qaias, Asmaa M; El-Behedy, Dina S; Hassanin, Alshaimaa A; El-Sayed, Selwan M; El-Messery, Shahenda M; Shaldam, Moataz A; Hassan, Ghada S.

Afiliação

Al-Rashood ST; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Elshahawy SS; Faculty of Pharmacy, Mansoura University, P.O.Box 35516, Mansoura, Egypt.
El-Qaias AM; Faculty of Pharmacy, Mansoura University, P.O.Box 35516, Mansoura, Egypt.
El-Behedy DS; Faculty of Pharmacy, Mansoura University, P.O.Box 35516, Mansoura, Egypt.
Hassanin AA; Faculty of Pharmacy, Mansoura University, P.O.Box 35516, Mansoura, Egypt.
El-Sayed SM; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, P.O.Box 35516, Mansoura, Egypt.
El-Messery SM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, P.O.Box 35516, Mansoura, Egypt. Electronic address: selmessery@gmail.com.
Shaldam MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafr El Sheikh 33516, Egypt.
Hassan GS; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, P.O.Box 35516, Mansoura, Egypt.

Bioorg Med Chem Lett ; 30(23): 127611, 2020 12 01.

Article em En | MEDLINE | ID: mdl-33068712

Assuntos

Antineoplásicos/farmacologia; DNA/metabolismo; Pirimidinas/farmacologia; Tiazóis/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/metabolismo; Antineoplásicos/farmacocinética; Linhagem Celular Tumoral; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Ligação de Hidrogênio; Simulação de Acoplamento Molecular; Pirimidinas/síntese química; Pirimidinas/metabolismo; Pirimidinas/farmacocinética; Tiazóis/síntese química; Tiazóis/metabolismo; Tiazóis/farmacocinética

Palavras-chave

ADMET; Antitumor; DNA-binding; Molecular docking; Purine; Synthesis; Thiazolopyrimidine

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Tiazóis / DNA / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google