Identification of a novel KMT2A/GIMAP8 gene fusion in a pediatric patient with acute undifferentiated leukemia.
Genes Chromosomes Cancer
; 60(2): 108-111, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-33078871
ABSTRACT
Acute undifferentiated leukemia (AUL) is a very rare hematologic neoplasm that expresses no markers specific for either myeloid or lymphoid lineages. While commonly observed in several acute leukemias, KMT2A rearrangements in AUL have been rarely reported in the literature. We report the third case to our knowledge of AUL harboring a KMT2A rearrangement. Furthermore, the KMT2A/GIMAP8 gene fusion identified in this case represents a novel KMT2A rearrangement.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Aguda Bifenotípica
/
Proteínas de Fusão Oncogênica
/
Histona-Lisina N-Metiltransferase
/
Proteína de Leucina Linfoide-Mieloide
/
GTP Fosfo-Hidrolases
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Child
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article