Helicobacter pylori infection with atrophic gastritis: An independent risk factor for colorectal adenomas.
World J Gastroenterol
; 26(37): 5682-5692, 2020 Oct 07.
Article
em En
| MEDLINE
| ID: mdl-33088161
ABSTRACT
BACKGROUND:
The significance of Helicobacter pylori (H. pylori) infection and atrophic gastritis (AG) in the prevalence of colorectal adenomas has been examined in a limited number of studies. However, these studies reported disputed conclusions.AIM:
To investigate whether H. pylori infection, AG, and H. pylori-related AG increase the risk of colorectal adenomas.METHODS:
This retrospective cross-sectional study included 6018 health-check individuals. The relevant data for physical examination, laboratory testing, 13C-urea breath testing, gastroscopy, colonoscopy and histopathological examination of gastric and colorectal biopsies were recorded. Univariate and multivariate logistic regression analyses were performed to determine the association between H. pylori-related AG and colorectal adenomas.RESULTS:
Overall, 1012 subjects (16.8%) were diagnosed with colorectal adenomas, of whom 143 (2.4%) had advanced adenomas. Among the enrolled patients, the prevalence of H. pylori infection and AG was observed as 49.5% (2981/6018) and 10.0% (602/6018), respectively. Subjects with H. pylori infection had an elevated risk of colorectal adenomas (adjusted odds ratio [OR] of 1.220, 95% confidence interval (CI) 1.053-1.413, P = 0.008) but no increased risk of advance adenomas (adjusted OR = 1.303, 95%CI 0.922-1.842, P = 0.134). AG was significantly correlated to an increased risk of colorectal adenomas (unadjusted OR = 1.668, 95%CI 1.352-2.059, P < 0.001; adjusted OR = 1.237, 95%CI 0.988-1.549, P = 0.064). H. pylori infection accompanied by AG was significantly associated with an increased risk of adenomas (adjusted OR = 1.491, 95%CI 1.103-2.015, P = 0.009) and advanced adenomas (adjusted OR = 1.910, 95%CI 1.022-3.572, P = 0.043).CONCLUSION:
H. pylori-related AG was associated with a high risk of colorectal adenomas and advanced adenomas in Chinese individuals.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Adenoma
/
Helicobacter pylori
/
Infecções por Helicobacter
/
Gastrite Atrófica
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article