Substrate recognition by TRIM and TRIM-like proteins in innate immunity.
Semin Cell Dev Biol
; 111: 76-85, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-33092958
ABSTRACT
TRIM (Tripartite motif) and TRIM-like proteins have emerged as an important class of E3 ligases in innate immunity. Their functions range from activation or regulation of innate immune signaling pathway to direct detection and restriction of pathogens. Despite the importance, molecular mechanisms for many TRIM/TRIM-like proteins remain poorly characterized, in part due to challenges of identifying their substrates. In this review, we discuss several TRIM/TRIM-like proteins in RNA sensing pathways and viral restriction functions. We focus on those containing PRY-SPRY, the domain most frequently used for substrate recognition, and discuss emerging mechanisms that are commonly utilized by several TRIM/TRIM-like proteins to tightly control their interaction with the substrates.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Imunológicos
/
Ubiquitina-Proteína Ligases
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Proteína DEAD-box 58
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Helicase IFIH1 Induzida por Interferon
/
Proteínas com Motivo Tripartido
/
Domínio B30.2-SPRY
/
Imunidade Inata
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article