Protofibril-Fibril Interactions Inhibit Amyloid Fibril Assembly by Obstructing Secondary Nucleation.

Hasecke, Filip; Niyangoda, Chamani; Borjas, Gustavo; Pan, Jianjun; Matthews, Garrett; Muschol, Martin; Hoyer, Wolfgang

Hasecke, Filip; Niyangoda, Chamani; Borjas, Gustavo; Pan, Jianjun; Matthews, Garrett; Muschol, Martin; Hoyer, Wolfgang.

Afiliação

Hasecke F; Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, 40204, Düsseldorf, Germany.
Niyangoda C; Department of Physics, University of South Florida, Tampa, FL, 33620, USA.
Borjas G; Department of Physics, University of South Florida, Tampa, FL, 33620, USA.
Pan J; Department of Physics, University of South Florida, Tampa, FL, 33620, USA.
Matthews G; Department of Physics, University of South Florida, Tampa, FL, 33620, USA.
Muschol M; Department of Physics, University of South Florida, Tampa, FL, 33620, USA.
Hoyer W; Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, 40204, Düsseldorf, Germany.

Angew Chem Int Ed Engl ; 60(6): 3016-3021, 2021 02 08.

Article em En | MEDLINE | ID: mdl-33095508

Assuntos

Peptídeos beta-Amiloides/metabolismo; Amiloide/metabolismo; Peptídeos beta-Amiloides/química; Peptídeos beta-Amiloides/genética; Cinética; Microscopia de Força Atômica; Muramidase/metabolismo; Agregados Proteicos/fisiologia; Ligação Proteica; Propriedades de Superfície

Palavras-chave

aggregates; fibrils; peptides; protein-protein interactions; self-assembly

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Amiloide Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google