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[1,2,4]Triazolo[1,5-a]pyrimidine Phosphodiesterase 2A Inhibitors: Structure and Free-Energy Perturbation-Guided Exploration.
Tresadern, Gary; Velter, Ingrid; Trabanco, Andrés A; Van den Keybus, Frans; Macdonald, Gregor J; Somers, Marijke V F; Vanhoof, Greet; Leonard, Philip M; Lamers, Marieke B A C; Van Roosbroeck, Yves E M; Buijnsters, Peter J J A.
Afiliação
  • Tresadern G; Computational Chemistry, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Velter I; Medicinal Chemistry, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Trabanco AA; Medicinal Chemistry, Janssen Research & Development, Janssen-Cilag S. A., Jarama 75A, 45007 Toledo, Spain.
  • Van den Keybus F; Medicinal Chemistry, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Macdonald GJ; Medicinal Chemistry, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Somers MVF; Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Vanhoof G; Discovery Sciences, Janssen Research & Development, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Leonard PM; Structural Biology, Charles River Discovery (Previously BioFocus), Chesterford Research Park, Saffron Walden, CB10 1XL Essex, U.K.
  • Lamers MBAC; Structural Biology, Charles River Discovery (Previously BioFocus), Chesterford Research Park, Saffron Walden, CB10 1XL Essex, U.K.
  • Van Roosbroeck YEM; Medicinal Chemistry, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
  • Buijnsters PJJA; Medicinal Chemistry, Janssen Pharmaceutica N. V., Turnhoutseweg 30, B-2340 Beerse, Belgium.
J Med Chem ; 63(21): 12887-12910, 2020 11 12.
Article em En | MEDLINE | ID: mdl-33105987
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Fosfodiesterase / Pirimidinas / Triazóis / Nucleotídeo Cíclico Fosfodiesterase do Tipo 2 Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Fosfodiesterase / Pirimidinas / Triazóis / Nucleotídeo Cíclico Fosfodiesterase do Tipo 2 Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article