Anti-inflammatory activity of glycolipids isolated from cyanobacterium Nodularia harveyana.
Nat Prod Res
; 35(24): 6204-6209, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-33111583
ABSTRACT
Activity-guided fractionations from the freshwater cyanobacterium Nodularia harveyana led to the isolation of two monogalactosyldiacylglycerols (MGDG), two digalactosyldiacylglycerols (DGDG), two monoglucosyldiacylglycerols (MGlcDG) and 1-(O-hexose)-3,25-hexacosanediol (HG). Structures were elucidated by a combination of 1D and 2D NMR analysis, HRMS and GC-MS. The potential for inhibition against TNF-α and NF-κB production of these seven compounds was tested in THP-1 cells. All compounds showed activity, but compound 7 showed higher inhibitory activity of TNF-α and NF-κB, with IC50 of 4.88 ± 0.13 and 3.64 ± 0.45 µM, respectively.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicolipídeos
/
Cianobactérias
/
Nodularia
/
Anti-Inflamatórios
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article