Radioprotective effects of lipid A, liposomes, and liposomes containing lipid A in mice.
Biochim Biophys Acta
; 903(3): 519-24, 1987 Oct 16.
Article
em En
| MEDLINE
| ID: mdl-3311165
ABSTRACT
Lipid A from Gram-negative bacterial lipopolysaccharide (endotoxin) was incorporated into liposomal membranes and examined as a prophylactic radioprotectant compound in lethally irradiated mice. Splenic hematopoietic activity, resulting in increased numbers of spleen cell colonies, was induced both by lipid A alone or more strongly by liposomal lipid A. Increased survival of lethally irradiated animals was induced to a slight extent by liposomes alone, to a greater extent by lipid A, and at the highest level by liposomes containing lipid A. Under conditions where 100% of untreated or saline-treated animals died of acute radiation syndrome after 20 days, more than 90% of the animals pretreated with liposomal lipid A were still alive 30 days after irradiation. We conclude that lipid A had substantial radioprotectant activity by itself, and the activity was enhanced by incorporation into liposomes. Liposomes alone also exhibited mild radioprotectant effects.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lesões Experimentais por Radiação
/
Protetores contra Radiação
/
Lipídeo A
/
Lipossomos
Limite:
Animals
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article