[Pathological and therapeutic possibilities in inhibiting ocular angionesis].
Ugeskr Laeger
; 182(44)2020 10 26.
Article
em Da
| MEDLINE
| ID: mdl-33118489
ABSTRACT
In a variety of corneal and retinal diseases, ocular ischaemia mediates vascular endothelial growth factor (VEGF) expression, which in turn causes angiogenesis and increased vascular permeability. Consequently, VEGF-inhibitory treatment has been introduced in different ocular diseases. Hypoxia-inducible factor (HIF)-1α is an upstream regulator of VEGF-A, and increased HIF-1α expression has been established in ocular animal models. Upcoming translational studies are expected to increase our understanding of the complex balance between pro- and anti-angiogenic factors in the eye.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator A de Crescimento do Endotélio Vascular
/
Indutores da Angiogênese
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Da
Ano de publicação:
2020
Tipo de documento:
Article