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Behavioral and Neurochemical Effects of Extra Virgin Olive Oil Total Phenolic Content and Sideritis Extract in Female Mice.
Kokras, Nikolaos; Poulogiannopoulou, Eleni; Sotiropoulos, Marinos G; Paravatou, Rafaella; Goudani, Eleni; Dimitriadou, Maria; Papakonstantinou, Electra; Doxastakis, George; Perrea, Despina N; Hloupis, George; Angelis, Apostolis; Argyropoulou, Aikaterini; Tsarbopoulos, Anthony; Skaltsounis, Alexios-Leandros; Dalla, Christina.
Afiliação
  • Kokras N; Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece.
  • Poulogiannopoulou E; First Department of Psychiatry, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Vas. Sofias Avenue 72-74, 11528 Athens, Greece.
  • Sotiropoulos MG; Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece.
  • Paravatou R; Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece.
  • Goudani E; Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece.
  • Dimitriadou M; Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece.
  • Papakonstantinou E; Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece.
  • Doxastakis G; Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece.
  • Perrea DN; Electronic Devices and Materials Laboratory, Department of Electrical and Electronic Engineering, School of Engineering, University of West Attica, Agiou Spiridonos 28, Egaleo, 12243 Athens, Greece.
  • Hloupis G; Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11521 Athens, Greece.
  • Angelis A; Electronic Devices and Materials Laboratory, Department of Electrical and Electronic Engineering, School of Engineering, University of West Attica, Agiou Spiridonos 28, Egaleo, 12243 Athens, Greece.
  • Argyropoulou A; Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
  • Tsarbopoulos A; Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
  • Skaltsounis AL; Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, Goudi, 11527 Athens, Greece.
  • Dalla C; Bioanalytical Department, GAIA Research Center, The Goulandris Natural History Museum, Othonos 100, Kifissia, 14562 Athens, Greece.
Molecules ; 25(21)2020 Oct 28.
Article em En | MEDLINE | ID: mdl-33126727
The aim of this study was to determine the cognitive and behavioral effects of extra virgin olive oil total phenolic content (TPC) and Sideritis (SID) extracts in female mice, and identify the associated neurochemical changes in the hippocampus and the prefrontal cortex. All animals received intraperitoneal low or high doses of TPC, SID or vehicle treatment for 7 days and were subjected to the Open Field (OF), Novel Object Recognition (NOR) and Tail Suspension Test (TST). The prefrontal cortex and hippocampus were dissected for analysis of neurotransmitters and aminoacids with high performance liquid chromatography with electrochemical detection (HPLC-ED). Both TPC doses enhanced vertical activity and center entries in the OF, which could indicate an anxiolytic-like effect. In addition, TPC enhanced non-spatial working memory and, in high doses, exerted antidepressant effects. On the other hand, high SID doses remarkably decreased the animals' overall activity. Locomotor and exploratory activities were closely associated with cortical increases in serotonin turnover induced by both treatments. Cognitive performance was linked to glutamate level changes. Furthermore, TPC reduced cortical taurine levels, while SID reduced cortical aspartate levels. TPC seems to have promising cognitive, anxiolytic and antidepressant effects, whereas SID has sedative effects in high doses. Both extracts act in the brain, but their specific actions and properties merit further exploration.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenóis / Comportamento Animal / Sideritis / Azeite de Oliva Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenóis / Comportamento Animal / Sideritis / Azeite de Oliva Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article