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An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid.
Perrone, Maria Grazia; Miciaccia, Morena; Vitale, Paola; Ferorelli, Savina; Araújo, Cristina da Costa Bernardes; de Almeida, Gabriella Silva; Souza Domingos, Thaisa Francielle; da Silva, Luiz Claudio Rodrigues Pereira; de Pádula, Marcelo; Cabral, Lucio Mendes; Sathler, Plínio Cunha; Bonaccorso, Carmela; Fortuna, Cosimo G; Scilimati, Antonio.
Afiliação
  • Perrone MG; Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", Via E. Orabona 4, 70125, Bari, Italy.
  • Miciaccia M; Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", Via E. Orabona 4, 70125, Bari, Italy.
  • Vitale P; Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", Via E. Orabona 4, 70125, Bari, Italy.
  • Ferorelli S; Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", Via E. Orabona 4, 70125, Bari, Italy.
  • Araújo CDCB; Faculty of Pharmacy, Federal University of Rio de Janeiro, Center of Health Sciences, Carlos Chagas Filho Avenue, 373, 21941599, Rio de Janeiro, Brazil.
  • de Almeida GS; Faculty of Pharmacy, Federal University of Rio de Janeiro, Center of Health Sciences, Carlos Chagas Filho Avenue, 373, 21941599, Rio de Janeiro, Brazil.
  • Souza Domingos TF; Faculty of Pharmacy, Federal University of Rio de Janeiro, Center of Health Sciences, Carlos Chagas Filho Avenue, 373, 21941599, Rio de Janeiro, Brazil.
  • da Silva LCRP; Faculty of Pharmacy, Federal University of Rio de Janeiro, Center of Health Sciences, Carlos Chagas Filho Avenue, 373, 21941599, Rio de Janeiro, Brazil.
  • de Pádula M; Faculty of Pharmacy, Federal University of Rio de Janeiro, Center of Health Sciences, Carlos Chagas Filho Avenue, 373, 21941599, Rio de Janeiro, Brazil.
  • Cabral LM; Faculty of Pharmacy, Federal University of Rio de Janeiro, Center of Health Sciences, Carlos Chagas Filho Avenue, 373, 21941599, Rio de Janeiro, Brazil.
  • Sathler PC; Faculty of Pharmacy, Federal University of Rio de Janeiro, Center of Health Sciences, Carlos Chagas Filho Avenue, 373, 21941599, Rio de Janeiro, Brazil.
  • Bonaccorso C; Department of Chemical Science, University of Catania, Viale Andrea Doria 6, 95125, Catania, Italy.
  • Fortuna CG; Department of Chemical Science, University of Catania, Viale Andrea Doria 6, 95125, Catania, Italy.
  • Scilimati A; Department of Pharmacy - Pharmaceutical Sciences, University of Bari "Aldo Moro", Via E. Orabona 4, 70125, Bari, Italy. Electronic address: antonio.scilimati@uniba.it.
Eur J Med Chem ; 209: 112919, 2021 Jan 01.
Article em En | MEDLINE | ID: mdl-33129592
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose / Anti-Inflamatórios não Esteroides / Inibidores de Ciclo-Oxigenase / Ácido Araquidônico / Ciclo-Oxigenase 1 / Isoxazóis Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose / Anti-Inflamatórios não Esteroides / Inibidores de Ciclo-Oxigenase / Ácido Araquidônico / Ciclo-Oxigenase 1 / Isoxazóis Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article