Toll-like receptor mediated lysozyme expression in Niemann-pick disease, type C1.
Mol Genet Metab
; 131(3): 364-366, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-33129690
ABSTRACT
Niemann-Pick type C1 (NPC1) is a rare neurodegenerative disease. In NPC1 mouse cerebella, the antibacterial enzyme, lysozyme (Lyz2), is significantly increased in multiple cell types. Due to its possible role in toxic fibril deposition, we confirmed Lyz2 overexpression in culture in different control and NPC1 cell types including human NPC1 fibroblasts. Lyz2 expression is induced by Toll-like receptors potentially in response to lipid storage but does not play a functional role in NPC disease pathology.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Muramidase
/
Peptídeos e Proteínas de Sinalização Intracelular
/
Receptores Toll-Like
/
Doença de Niemann-Pick Tipo C
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article