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New methyl 5-(halomethyl)-1-aryl-1H-1,2,4-triazole-3-carboxylates as selective COX-2 inhibitors and anti-inflammatory agents: Design, synthesis, biological evaluation, and docking study.
Li, Sin-Min; Tsai, Shuo-En; Chiang, Chia-Yin; Chung, Cheng-Yen; Chuang, Tsung-Jui; Tseng, Ching-Chun; Jiang, Wen-Ping; Huang, Guan-Jhong; Lin, Chin-Yu; Yang, Ya-Chen; Fuh, Mao-Tsu; Wong, Fung-Fuh.
Afiliação
  • Li SM; Institute of New Drug Development, China Medical University, No. 91 Hsueh-Shih Rd., Taichung 40402, Taiwan.
  • Tsai SE; Ph.D. Program for Biotech Pharmaceutical Industry, China Medical University, No. 91, Hsueh-Shih Rd., Taichung 40402, Taiwan.
  • Chiang CY; Ph.D. Program for Biotech Pharmaceutical Industry, China Medical University, No. 91, Hsueh-Shih Rd., Taichung 40402, Taiwan.
  • Chung CY; Ph.D. Program for Biotech Pharmaceutical Industry, China Medical University, No. 91, Hsueh-Shih Rd., Taichung 40402, Taiwan; School of Pharmacy, China Medical University, No. 91, Hsueh-Shih Rd., Taichung 40402, Taiwan.
  • Chuang TJ; Master Program for Pharmaceutical Manufacture, China Medical University, No. 91, Hsueh-Shih Rd., Taichung 40402, Taiwan.
  • Tseng CC; Ph.D. Program for Biotech Pharmaceutical Industry, China Medical University, No. 91, Hsueh-Shih Rd., Taichung 40402, Taiwan.
  • Jiang WP; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, No. 91, Hsueh-Shih Rd., Taichung 40402, Taiwan.
  • Huang GJ; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, No. 91, Hsueh-Shih Rd., Taichung 40402, Taiwan.
  • Lin CY; Institute of New Drug Development, China Medical University, No. 91 Hsueh-Shih Rd., Taichung 40402, Taiwan.
  • Yang YC; Department of Food Nutrition and Health Biotechnology, Asia University, Taichung 41354, Taiwan.
  • Fuh MT; Division of Metabolism, Department of Internal Medicine, China Medical University, Taichung 40402, Taiwan.
  • Wong FF; Ph.D. Program for Biotech Pharmaceutical Industry, China Medical University, No. 91, Hsueh-Shih Rd., Taichung 40402, Taiwan; School of Pharmacy, China Medical University, No. 91, Hsueh-Shih Rd., Taichung 40402, Taiwan. Electronic address: ffwong@mail.cmu.edu.tw.
Bioorg Chem ; 104: 104333, 2020 11.
Article em En | MEDLINE | ID: mdl-33142408
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triazóis / Ácidos Carboxílicos / Desenho de Fármacos / Anti-Inflamatórios não Esteroides / Inibidores de Ciclo-Oxigenase 2 / Simulação de Acoplamento Molecular Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triazóis / Ácidos Carboxílicos / Desenho de Fármacos / Anti-Inflamatórios não Esteroides / Inibidores de Ciclo-Oxigenase 2 / Simulação de Acoplamento Molecular Idioma: En Ano de publicação: 2020 Tipo de documento: Article