Cytochalasins from an endophytic fungus Phoma multirostrata XJ-2-1 with cell cycle arrest and TRAIL-resistance-overcoming activities.

Peng, Xiaogang; He, Yangzhou; Gao, Ying; Duan, Fangfang; Chen, Juan; Ruan, Hanli

Peng, Xiaogang; He, Yangzhou; Gao, Ying; Duan, Fangfang; Chen, Juan; Ruan, Hanli.

Afiliação

Peng X; School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People's Republic of China.
He Y; School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People's Republic of China.
Gao Y; School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People's Republic of China.
Duan F; School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People's Republic of China.
Chen J; School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People's Republic of China.
Ruan H; School of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People's Republic of China. Electronic address: ruanhl@mails.tjmu.edu.cn.

Bioorg Chem ; 104: 104317, 2020 11.

Article em En | MEDLINE | ID: mdl-33142426

Assuntos

Antineoplásicos/farmacologia; Citocalasinas/farmacologia; Phoma/química; Ligante Indutor de Apoptose Relacionado a TNF/antagonistas & inibidores; Antineoplásicos/química; Antineoplásicos/isolamento & purificação; Apoptose/efeitos dos fármacos; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Citocalasinas/química; Citocalasinas/isolamento & purificação; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Estrutura Molecular; Phoma/metabolismo; Relação Estrutura-Atividade; Ligante Indutor de Apoptose Relacionado a TNF/metabolismo; Células Tumorais Cultivadas

Palavras-chave

Cell cycle arrest; Cytochalasins; Cytotoxicity; Endophytic fungus; Phoma multirostrata XJ-2-1; TRAIL sensitizer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocalasinas / Ligante Indutor de Apoptose Relacionado a TNF / Phoma / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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