Oxysophocarpine suppresses FGFR1-overexpressed hepatocellular carcinoma growth and sensitizes the therapeutic effect of lenvatinib.

Zhao, Zhongwei; Song, Jingjing; Zhang, Dengke; Wu, Fazong; Tu, Jianfei; Ji, Jiansong

Zhao, Zhongwei; Song, Jingjing; Zhang, Dengke; Wu, Fazong; Tu, Jianfei; Ji, Jiansong.

Afiliação

Zhao Z; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, the Fifth Affiliated
Song J; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, the Fifth Affiliated
Zhang D; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, the Fifth Affiliated
Wu F; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, the Fifth Affiliated
Tu J; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, the Fifth Affiliated
Ji J; Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, the Fifth Affiliated

Life Sci ; 264: 118642, 2021 Jan 01.

Article em En | MEDLINE | ID: mdl-33148422

Assuntos

Alcaloides/uso terapêutico; Carcinoma Hepatocelular/tratamento farmacológico; Carcinoma Hepatocelular/patologia; Neoplasias Hepáticas/tratamento farmacológico; Neoplasias Hepáticas/patologia; Receptor Tipo 1 de Fator de Crescimento de Fibroblastos/metabolismo; Alcaloides/farmacologia; Animais; Apoptose/efeitos dos fármacos; Carcinoma Hepatocelular/genética; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Regulação para Baixo/efeitos dos fármacos; Regulação para Baixo/genética; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Resistencia a Medicamentos Antineoplásicos/genética; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Neoplasias Hepáticas/genética; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Masculino; Camundongos Endogâmicos BALB C; Camundongos Nus; Compostos de Fenilureia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Quinolinas; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

FGFR1; Hepatocellular carcinoma; Lenvatinib; Oxysophocarpine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Alcaloides / Receptor Tipo 1 de Fator de Crescimento de Fibroblastos / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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