The Pyrazolo[3,4-<i>d</i>]pyrimidine-Based Kinase Inhibitor NVP-BHG712: Effects of Regioisomers on Tumor Growth, Perfusion, and Hypoxia in EphB4-Positive A375 Melanoma Xenografts.

Neuber, Christin; Tröster, Alix; Löser, Reik; Belter, Birgit; Schwalbe, Harald; Pietzsch, Jens

The Pyrazolo[3,4-d]pyrimidine-Based Kinase Inhibitor NVP-BHG712: Effects of Regioisomers on Tumor Growth, Perfusion, and Hypoxia in EphB4-Positive A375 Melanoma Xenografts.

Neuber, Christin; Tröster, Alix; Löser, Reik; Belter, Birgit; Schwalbe, Harald; Pietzsch, Jens.

Afiliação

Neuber C; Institute of Radiopharmaceutical Cancer Research, Department Radiopharmaceutical and Chemical Biology, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstrasse 400, 01328 Dresden, Germany.
Tröster A; Centre for Biomolecular Magnetic Resonance (BMRZ), Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University Frankfurt a. M., Max-von-Laue-Strasse 7, 60438 Frankfurt, Germany.
Löser R; Institute of Radiopharmaceutical Cancer Research, Department Radiopharmaceutical and Chemical Biology, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstrasse 400, 01328 Dresden, Germany.
Belter B; Faculty of Chemistry and Food Chemistry, School of Science, Technische Universität Dresden, 01069 Dresden, Germany.
Schwalbe H; Institute of Radiopharmaceutical Cancer Research, Department Radiopharmaceutical and Chemical Biology, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstrasse 400, 01328 Dresden, Germany.
Pietzsch J; Centre for Biomolecular Magnetic Resonance (BMRZ), Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe-University Frankfurt a. M., Max-von-Laue-Strasse 7, 60438 Frankfurt, Germany.

Molecules ; 25(21)2020 Nov 03.

Article em En | MEDLINE | ID: mdl-33153234

Assuntos

Proliferação de Células/efeitos dos fármacos; Melanoma Experimental; Proteínas de Neoplasias; Inibidores de Proteínas Quinases/farmacologia; Pirazóis/farmacologia; Pirimidinas/farmacologia; Receptor EphB4/metabolismo; Animais; Hipóxia Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Humanos; Melanoma Experimental/tratamento farmacológico; Melanoma Experimental/enzimologia; Melanoma Experimental/patologia; Camundongos; Proteínas de Neoplasias/antagonistas & inibidores; Proteínas de Neoplasias/metabolismo; Transdução de Sinais/efeitos dos fármacos; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

eph receptor tyrosin kinase family; ephrins; regioisomers; tumor angiogenesis; tumor hypoxia; tumor perfusion; tyrosine kinase inhibitors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Melanoma Experimental / Receptor EphB4 / Inibidores de Proteínas Quinases / Proliferação de Células / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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