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De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2.
Linsky, Thomas W; Vergara, Renan; Codina, Nuria; Nelson, Jorgen W; Walker, Matthew J; Su, Wen; Barnes, Christopher O; Hsiang, Tien-Ying; Esser-Nobis, Katharina; Yu, Kevin; Reneer, Z Beau; Hou, Yixuan J; Priya, Tanu; Mitsumoto, Masaya; Pong, Avery; Lau, Uland Y; Mason, Marsha L; Chen, Jerry; Chen, Alex; Berrocal, Tania; Peng, Hong; Clairmont, Nicole S; Castellanos, Javier; Lin, Yu-Ru; Josephson-Day, Anna; Baric, Ralph S; Fuller, Deborah H; Walkey, Carl D; Ross, Ted M; Swanson, Ryan; Bjorkman, Pamela J; Gale, Michael; Blancas-Mejia, Luis M; Yen, Hui-Ling; Silva, Daniel-Adriano.
Afiliação
  • Linsky TW; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Vergara R; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Codina N; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Nelson JW; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Walker MJ; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Su W; School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Barnes CO; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
  • Hsiang TY; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, WA, USA.
  • Esser-Nobis K; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, WA, USA.
  • Yu K; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Reneer ZB; Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA.
  • Hou YJ; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, WA, USA.
  • Priya T; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Mitsumoto M; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Pong A; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Lau UY; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Mason ML; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Chen J; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Chen A; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Berrocal T; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Peng H; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Clairmont NS; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Castellanos J; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Lin YR; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Josephson-Day A; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Fuller DH; Department of Microbiology, University of Washington, Seattle, WA, USA.
  • Walkey CD; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Ross TM; Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA.
  • Swanson R; Department of Infectious Diseases, University of Georgia, Athens, GA, USA.
  • Bjorkman PJ; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Gale M; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
  • Blancas-Mejia LM; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington, Seattle, WA, USA.
  • Yen HL; Neoleukin Therapeutics Inc., Seattle, WA, USA.
  • Silva DA; School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China.
Science ; 370(6521): 1208-1214, 2020 12 04.
Article em En | MEDLINE | ID: mdl-33154107
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Receptores Virais / Proteínas Recombinantes / Glicoproteína da Espícula de Coronavírus / Enzima de Conversão de Angiotensina 2 / SARS-CoV-2 / Tratamento Farmacológico da COVID-19 Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Receptores Virais / Proteínas Recombinantes / Glicoproteína da Espícula de Coronavírus / Enzima de Conversão de Angiotensina 2 / SARS-CoV-2 / Tratamento Farmacológico da COVID-19 Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article