PDL1 and IDO1 expression in undifferentiated pleomorphic sarcoma: The associations with tumor infiltrating lymphocytes, dMMR and HLA class I.
Oncol Rep
; 45(1): 379-389, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-33155664
ABSTRACT
The prognosis of undifferentiated pleomorphic sarcoma (UPS) is generally unfavorable. Recently, clinical trials such as SARC028 demonstrated the utility of cancer immunotherapy for soft tissue sarcomas. The aim of the present study was to assess the expression of PDL1 and IDO1 as prognostic factors and therapeutic targets. A total of 52 primary UPS cases were retrieved and two UPS cell lines were utilized for supplementary analysis. Immunohistochemical staining of antiPDL1 (288), IDO1, CD8, CD4, CD3, HLA class I, MSH2, MSH6, MLH1 and PMS2 was carried out. Immunohistochemically, 19 of 52 (36.5%) cases showed PDL1 expression at least focally (≥1%) and 5 of 52 (9.62%) showed strong PDL1 expression (≥50%). Overall, 25 of 52 (48.1%) cases expressed IDO1 (≥1%). Two tumors were evaluated as having deficient mismatch repair and six tumors as having the loss of HLA class I. PDL1 expression (≥1%) was significantly related to the infiltration of CD8 and CD3positive lymphocytes, but strong PDL1 expression (≥50%) did not present a significant relationship with tumorinfiltrating lymphocytes. IDO1 expression was also associated with CD8, CD4, and CD3positive lymphocytes. In vitro, both PDL1 and IDO1 were induced by IFNγ stimulation. In survival analysis, strong PDL1 expression (≥50%) was a significant poor prognostic factor, while IDO1 expression (≥1%) was a favorable one. In conclusion, UPS was shown to frequently express PDL1 and IDO1. It was suggested that PDL1 expression (≥50%) and IDO1 expression are poor and favorable prognostic factors of UPS patients, respectively.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sarcoma
/
Síndromes Neoplásicas Hereditárias
/
Neoplasias Encefálicas
/
Neoplasias Colorretais
/
Antígenos de Histocompatibilidade Classe I
/
Linfócitos do Interstício Tumoral
/
Indolamina-Pirrol 2,3,-Dioxigenase
/
Antígeno B7-H1
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article