MicroRNA-146b-5p overexpression attenuates premature ovarian failure in mice by inhibiting the Dab2ip/Ask1/p38-Mapk pathway and Î³H2A.X phosphorylation.

Liu, Te; Lin, Jiajia; Chen, Chuan; Nie, Xiaoli; Dou, Fangfang; Chen, Jiulin; Wang, Zhenxin; Gong, Zhangbin

Liu, Te; Lin, Jiajia; Chen, Chuan; Nie, Xiaoli; Dou, Fangfang; Chen, Jiulin; Wang, Zhenxin; Gong, Zhangbin.

Afiliação

Liu T; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Lin J; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Chen C; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Nie X; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Dou F; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Chen J; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wang Z; Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Gong Z; Department of Laboratory Medicine of Zhongshan Hospital and Institute of Biomedical Science, Fudan University, Shanghai, China.

Cell Prolif ; 54(1): e12954, 2021 Jan.

Article em En | MEDLINE | ID: mdl-33166004

Assuntos

Histonas/metabolismo; MAP Quinase Quinase Quinase 5/metabolismo; MicroRNAs/genética; Insuficiência Ovariana Primária/genética; Proteínas Ativadoras de ras GTPase/metabolismo; Animais; Células Cultivadas; Modelos Animais de Doenças; Feminino; Camundongos; Camundongos Endogâmicos C57BL; MicroRNAs/metabolismo; Fosforilação; Insuficiência Ovariana Primária/metabolismo; Insuficiência Ovariana Primária/patologia; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

Palavras-chave

DAB2IP/ASK1/p38 pathway; high-fat and high-sugar diet; miR-146b-5p (miR-146); poly (lactic-co-glycolic acid) nanoparticles; premature ovarian failure; Î³H2A.X

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Histonas / Insuficiência Ovariana Primária / Proteínas Ativadoras de ras GTPase / MicroRNAs / MAP Quinase Quinase Quinase 5 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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