MicroRNA-520c-3p targeting of RelA/p65 suppresses atherosclerotic plaque formation.

Wang, Jingyu; Hu, Xiaoyan; Hu, Xinxin; Gao, Fuhua; Li, Mei; Cui, Ying; Wei, Xiaoqing; Qin, Yuanhua; Zhang, Chenghong; Zhao, Ying; Gao, Ying

MicroRNA-520c-3p targeting of RelA/p65 suppresses atherosclerotic plaque formation.

Wang, Jingyu; Hu, Xiaoyan; Hu, Xinxin; Gao, Fuhua; Li, Mei; Cui, Ying; Wei, Xiaoqing; Qin, Yuanhua; Zhang, Chenghong; Zhao, Ying; Gao, Ying.

Afiliação

Wang J; Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Hu X; Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Hu X; Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Gao F; Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Li M; Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Cui Y; Liaoning Provincial Core Lab of Medical Molecular Biology, Dalian Medical University, Dalian, China.
Wei X; Liaoning Provincial Core Lab of Medical Molecular Biology, Dalian Medical University, Dalian, China.
Qin Y; Department of Parasite, College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Zhang C; Morphological Laboratory, College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Zhao Y; Liaoning Provincial Core Lab of Medical Molecular Biology, Dalian Medical University, Dalian, China. Electronic address: zhaoying20001105@126.com.
Gao Y; Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Dalian Medical University, Dalian, China; Liaoning Provincial Core Lab of Medical Molecular Biology, Dalian Medical University, Dalian, China. Electronic address: gaoying200018@126.com.

Int J Biochem Cell Biol ; 131: 105873, 2021 02.

Article em En | MEDLINE | ID: mdl-33166679

Assuntos

Aterosclerose/genética; MicroRNAs/genética; Miócitos de Músculo Liso/metabolismo; Placa Aterosclerótica/genética; Fator de Transcrição RelA/genética; Animais; Valva Aórtica/metabolismo; Valva Aórtica/patologia; Aterosclerose/metabolismo; Aterosclerose/patologia; Aterosclerose/terapia; Becaplermina/farmacologia; Linhagem Celular; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Modelos Animais de Doenças; Regulação da Expressão Gênica; Genes Reporter; Humanos; Luciferases/genética; Luciferases/metabolismo; Camundongos; Camundongos Knockout para ApoE; MicroRNAs/agonistas; MicroRNAs/antagonistas & inibidores; MicroRNAs/metabolismo; Músculo Liso Vascular/metabolismo; Músculo Liso Vascular/patologia; Miócitos de Músculo Liso/efeitos dos fármacos; Miócitos de Músculo Liso/patologia; Oligorribonucleotídeos/genética; Oligorribonucleotídeos/metabolismo; Placa Aterosclerótica/metabolismo; Placa Aterosclerótica/patologia; Placa Aterosclerótica/terapia; Cultura Primária de Células; Transdução de Sinais; Fator de Transcrição RelA/metabolismo

Palavras-chave

Atherosclerosis; Migration; Proliferation; VSMC; miR-520c-3p

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Miócitos de Músculo Liso / MicroRNAs / Aterosclerose / Fator de Transcrição RelA / Placa Aterosclerótica Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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