Stac protein regulates release of neuropeptides.
Proc Natl Acad Sci U S A
; 117(47): 29914-29924, 2020 11 24.
Article
em En
| MEDLINE
| ID: mdl-33168737
ABSTRACT
Neuropeptides are important for regulating numerous neural functions and behaviors. Release of neuropeptides requires long-lasting, high levels of cytosolic Ca2+ However, the molecular regulation of neuropeptide release remains to be clarified. Recently, Stac3 was identified as a key regulator of L-type Ca2+ channels (CaChs) and excitation-contraction coupling in vertebrate skeletal muscles. There is a small family of stac genes in vertebrates with other members expressed by subsets of neurons in the central nervous system. The function of neural Stac proteins, however, is poorly understood. Drosophila melanogaster contain a single stac gene, Dstac, which is expressed by muscles and a subset of neurons, including neuropeptide-expressing motor neurons. Here, genetic manipulations, coupled with immunolabeling, Ca2+ imaging, electrophysiology, and behavioral analysis, revealed that Dstac regulates L-type CaChs (Dmca1D) in Drosophila motor neurons and this, in turn, controls the release of neuropeptides.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neuropeptídeos
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Canais de Cálcio
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Proteínas de Drosophila
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Peptídeos e Proteínas de Sinalização Intracelular
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Neurônios Motores
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Junção Neuromuscular
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article