Intestinal Epithelium-Derived Luminally Released Extracellular Vesicles in Sepsis Exhibit the Ability to Suppress TNF-a and IL-17A Expression in Mucosal Inflammation.

Appiah, Michael G; Park, Eun Jeong; Darkwah, Samuel; Kawamoto, Eiji; Akama, Yuichi; Gaowa, Arong; Kalsan, Manisha; Ahmad, Shandar; Shimaoka, Motomu

Appiah, Michael G; Park, Eun Jeong; Darkwah, Samuel; Kawamoto, Eiji; Akama, Yuichi; Gaowa, Arong; Kalsan, Manisha; Ahmad, Shandar; Shimaoka, Motomu.

Afiliação

Appiah MG; Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
Park EJ; Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
Darkwah S; Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
Kawamoto E; Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
Akama Y; Department of Emergency and Critical Care Center, Mie University Hospital, Tsu, Mie 514-8507, Japan.
Gaowa A; Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
Kalsan M; Department of Emergency and Critical Care Center, Mie University Hospital, Tsu, Mie 514-8507, Japan.
Ahmad S; Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
Shimaoka M; School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi 110067, India.

Int J Mol Sci ; 21(22)2020 Nov 10.

Article em En | MEDLINE | ID: mdl-33182773

Assuntos

Interleucina-17/metabolismo; Mucosa Intestinal/imunologia; Sepse/imunologia; Fator de Necrose Tumoral alfa/metabolismo; Animais; Colite/genética; Colite/imunologia; Colite/patologia; Modelos Animais de Doenças; Exossomos/imunologia; Exossomos/patologia; Vesículas Extracelulares/imunologia; Vesículas Extracelulares/patologia; Humanos; Inflamação/genética; Inflamação/imunologia; Inflamação/patologia; Interleucina-17/antagonistas & inibidores; Interleucina-17/genética; Mucosa Intestinal/patologia; Camundongos; Camundongos Endogâmicos BALB C; MicroRNAs/genética; MicroRNAs/metabolismo; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Sepse/genética; Sepse/patologia; Fator de Necrose Tumoral alfa/antagonistas & inibidores; Fator de Necrose Tumoral alfa/genética

Palavras-chave

IL-17A; TNF-a; extracellular vesicles; inflammation; intestinal epithelial cells; miRNAs; sepsis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Necrose Tumoral alfa / Sepse / Interleucina-17 / Mucosa Intestinal Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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