Glioblastoma stem cells induce quiescence in surrounding neural stem cells via Notch signaling.
Genes Dev
; 34(23-24): 1599-1604, 2020 12 01.
Article
em En
| MEDLINE
| ID: mdl-33184225
ABSTRACT
There is increasing evidence demonstrating that adult neural stem cells (NSCs) are a cell of origin of glioblastoma. Here we analyzed the interaction between transformed and wild-type NSCs isolated from the adult mouse subventricular zone niche. We found that transformed NSCs are refractory to quiescence-inducing signals. Unexpectedly, we also demonstrated that these cells induce quiescence in surrounding wild-type NSCs in a cell-cell contact and Notch signaling-dependent manner. Our findings therefore suggest that oncogenic mutations are propagated in the stem cell niche not just through cell-intrinsic advantages, but also by outcompeting neighboring stem cells through repression of their proliferation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Neoplásicas
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Transdução de Sinais
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Glioblastoma
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Receptores Notch
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Células-Tronco Neurais
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article