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Discovery of CJ-2360 as a Potent and Orally Active Inhibitor of Anaplastic Lymphoma Kinase Capable of Achieving Complete Tumor Regression.
Chen, Jianyong; Zhou, Yunlong; Dong, Xuyuan; Liu, Liu; Bai, Longchuan; McEachern, Donna; Przybranowski, Sally; Yang, Chao-Yie; Stuckey, Jeanne; Li, Xiaoqin; Wen, Bo; Zhao, Ting; Sun, Siwei; Sun, Duxin; Jiao, Lingling; Jing, Yu; Guo, Ming; Yang, Dajun; Wang, Shaomeng.
Afiliação
  • Chen J; Rogel Cancer Center and Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Zhou Y; Ascentage Pharma (Jiangsu), Medical City Avenue, QB3 Building First Floor, Taizhou, Jiangsu Province 225300, China.
  • Dong X; Ascentage Pharma (Jiangsu), Medical City Avenue, QB3 Building First Floor, Taizhou, Jiangsu Province 225300, China.
  • Liu L; Rogel Cancer Center and Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Bai L; Rogel Cancer Center and Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • McEachern D; Rogel Cancer Center and Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Przybranowski S; Rogel Cancer Center and Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Yang CY; Rogel Cancer Center and Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Stuckey J; Rogel Cancer Center and Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Li X; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Wen B; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Zhao T; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Sun S; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Sun D; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Jiao L; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Jing Y; Ascentage Pharma (Jiangsu), Medical City Avenue, QB3 Building First Floor, Taizhou, Jiangsu Province 225300, China.
  • Guo M; Ascentage Pharma (Jiangsu), Medical City Avenue, QB3 Building First Floor, Taizhou, Jiangsu Province 225300, China.
  • Yang D; Ascentage Pharma (Jiangsu), Medical City Avenue, QB3 Building First Floor, Taizhou, Jiangsu Province 225300, China.
  • Wang S; Ascentage Pharma (Jiangsu), Medical City Avenue, QB3 Building First Floor, Taizhou, Jiangsu Province 225300, China.
J Med Chem ; 63(22): 13994-14016, 2020 11 25.
Article em En | MEDLINE | ID: mdl-33185101
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfoma Anaplásico de Células Grandes / Inibidores de Proteínas Quinases / Descoberta de Drogas / Quinase do Linfoma Anaplásico / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfoma Anaplásico de Células Grandes / Inibidores de Proteínas Quinases / Descoberta de Drogas / Quinase do Linfoma Anaplásico / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article