2,5-Hexanedione influences primordial follicular development in cultured neonatal mouse ovaries by interfering with the PI3K signaling pathway via miR-214-3p.

Zeng, Jingwen; Sun, Yan; Li, Xiaoqin; Zhu, Jianlin; Zhang, Wenchang; Lu, Wenmin; Weng, Yuyao; Liu, Jin

Zeng, Jingwen; Sun, Yan; Li, Xiaoqin; Zhu, Jianlin; Zhang, Wenchang; Lu, Wenmin; Weng, Yuyao; Liu, Jin.

Afiliação

Zeng J; Department of Preventive Medicine, School of Public Health, Fujian Medical University, Xueyan Road No. 1, Minhou County, Fuzhou 350108, China.
Sun Y; Reproductive Medicine Center, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Li X; Department of Preventive Medicine, School of Public Health, Fujian Medical University, Xueyan Road No. 1, Minhou County, Fuzhou 350108, China.
Zhu J; Department of Preventive Medicine, School of Public Health, Fujian Medical University, Xueyan Road No. 1, Minhou County, Fuzhou 350108, China.
Zhang W; Department of Preventive Medicine, School of Public Health, Fujian Medical University, Xueyan Road No. 1, Minhou County, Fuzhou 350108, China.
Lu W; Department of Preventive Medicine, School of Public Health, Fujian Medical University, Xueyan Road No. 1, Minhou County, Fuzhou 350108, China.
Weng Y; Department of Preventive Medicine, School of Public Health, Fujian Medical University, Xueyan Road No. 1, Minhou County, Fuzhou 350108, China.
Liu J; Department of Preventive Medicine, School of Public Health, Fujian Medical University, Xueyan Road No. 1, Minhou County, Fuzhou 350108, China. Electronic address: liujin@fjmu.edu.cn.

Toxicol Appl Pharmacol ; 409: 115335, 2020 12 15.

Article em En | MEDLINE | ID: mdl-33197454

Assuntos

Hexanonas/farmacologia; MicroRNAs/metabolismo; Folículo Ovariano/efeitos dos fármacos; Ovário/efeitos dos fármacos; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais/efeitos dos fármacos; Animais; Animais Recém-Nascidos; Apoptose/efeitos dos fármacos; Feminino; Camundongos; Oócitos/efeitos dos fármacos; Oócitos/metabolismo; Folículo Ovariano/metabolismo; Ovário/metabolismo

Palavras-chave

2,5-Hexanedione; Follicular development; PI3K signaling pathway; microRNAs

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ovário / Transdução de Sinais / Fosfatidilinositol 3-Quinases / MicroRNAs / Proteínas Proto-Oncogênicas c-akt / Folículo Ovariano / Hexanonas Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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