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Mutational drivers of cancer cell migration and invasion.
Novikov, Nikita M; Zolotaryova, Sofia Y; Gautreau, Alexis M; Denisov, Evgeny V.
Afiliação
  • Novikov NM; Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Zolotaryova SY; Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
  • Gautreau AM; CNRS UMR7654, Ecole Polytechnique, Institut Polytechnique de Paris, Palaiseau, France.
  • Denisov EV; School of Biological and Medical Physics, Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
Br J Cancer ; 124(1): 102-114, 2021 01.
Article em En | MEDLINE | ID: mdl-33204027
Genomic instability and mutations underlie the hallmarks of cancer-genetic alterations determine cancer cell fate by affecting cell proliferation, apoptosis and immune response, and increasing data show that mutations are involved in metastasis, a crucial event in cancer progression and a life-threatening problem in cancer patients. Invasion is the first step in the metastatic cascade, when tumour cells acquire the ability to move, penetrate into the surrounding tissue and enter lymphatic and blood vessels in order to disseminate. A role for genetic alterations in invasion is not universally accepted, with sceptics arguing that cellular motility is related only to external factors such as hypoxia, chemoattractants and the rigidity of the extracellular matrix. However, increasing evidence shows that mutations might trigger and accelerate the migration and invasion of different types of cancer cells. In this review, we summarise data from published literature on the effect of chromosomal instability and genetic mutations on cancer cell migration and invasion.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Movimento Celular / Invasividade Neoplásica / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Movimento Celular / Invasividade Neoplásica / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article