Cyclin G2 upregulation impairs migration, invasion, and network formation through RNF123/Dvl2/JNK signaling in the trophoblast cell line HTR8/SVneo, a possible role in preeclampsia.

Sun, Manni; Gao, Jinlan; Meng, Tao; Liu, Shenghuan; Chen, Haiying; Liu, Qi; Xing, Xuesha; Zhao, Chenyang; Luo, Yang

Sun, Manni; Gao, Jinlan; Meng, Tao; Liu, Shenghuan; Chen, Haiying; Liu, Qi; Xing, Xuesha; Zhao, Chenyang; Luo, Yang.

Afiliação

Sun M; The Research Center for Medical Genomics, Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Science, China Medical University, Shenyang, PR China.
Gao J; The Research Center for Medical Genomics, Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Science, China Medical University, Shenyang, PR China.
Meng T; Department of Obstetrics, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, PR China.
Liu S; The Research Center for Medical Genomics, Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Science, China Medical University, Shenyang, PR China.
Chen H; Department of Obstetrics, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, PR China.
Liu Q; The Research Center for Medical Genomics, Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Science, China Medical University, Shenyang, PR China.
Xing X; The Research Center for Medical Genomics, Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Science, China Medical University, Shenyang, PR China.
Zhao C; The Research Center for Medical Genomics, Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Science, China Medical University, Shenyang, PR China.
Luo Y; The Research Center for Medical Genomics, Key Laboratory of Medical Cell Biology, Ministry of Education, School of Life Science, China Medical University, Shenyang, PR China.

FASEB J ; 35(2): e21169, 2021 02.

Article em En | MEDLINE | ID: mdl-33205477

Assuntos

Movimento Celular/genética; Ciclina G1/metabolismo; Ciclina G2/metabolismo; Proteínas Desgrenhadas/metabolismo; Sistema de Sinalização das MAP Quinases/genética; Pré-Eclâmpsia/metabolismo; Trofoblastos/metabolismo; Ubiquitina-Proteína Ligases/metabolismo; Regulação para Cima/genética; Adulto; Animais; Linhagem Celular; Ciclina G1/genética; Ciclina G2/genética; Modelos Animais de Doenças; Feminino; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Pré-Eclâmpsia/genética; Pré-Eclâmpsia/patologia; Gravidez; Transfecção; Ubiquitina-Proteína Ligases/genética

Palavras-chave

CCNG2; Dvl2; RNF123; Wnt/PCP signaling; trophoblast

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pré-Eclâmpsia / Trofoblastos / Regulação para Cima / Movimento Celular / Sistema de Sinalização das MAP Quinases / Ubiquitina-Proteína Ligases / Ciclina G1 / Ciclina G2 / Proteínas Desgrenhadas Limite: Adult / Animals / Female / Humans / Male / Pregnancy Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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