Synthesis, biological evaluation, and molecular docking analysis of phenstatin based indole linked chalcones as anticancer agents and tubulin polymerization inhibitors.

Kode, Jyoti; Kovvuri, Jeshma; Nagaraju, Burri; Jadhav, Shailesh; Barkume, Madan; Sen, Subrata; Kasinathan, Nirmal Kumar; Chaudhari, Pradip; Mohanty, Bhabani Shankar; Gour, Jitendra; Sigalapalli, Dilep Kumar; Ganesh Kumar, C; Pradhan, Trupti; Banerjee, Manisha; Kamal, Ahmed

Kode, Jyoti; Kovvuri, Jeshma; Nagaraju, Burri; Jadhav, Shailesh; Barkume, Madan; Sen, Subrata; Kasinathan, Nirmal Kumar; Chaudhari, Pradip; Mohanty, Bhabani Shankar; Gour, Jitendra; Sigalapalli, Dilep Kumar; Ganesh Kumar, C; Pradhan, Trupti; Banerjee, Manisha; Kamal, Ahmed.

Afiliação

Kode J; Anti-Cancer Drug Screening Facility (ACDSF), Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India; Tumor Immunology & Immunotherapy Group, Advanced Centre for Treatment, Research & Education in Cancer (ACTREC),
Kovvuri J; Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi 110025, India; Department of Humanities and Sciences, Vardhaman College of Engineering (Autonomous), Shamsha
Nagaraju B; Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi 110025, India. Electronic address: nagarajuburri999@gmail.com.
Jadhav S; Anti-Cancer Drug Screening Facility (ACDSF), Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India. Electronic address: shaileshvjadhav55@gmail.com.
Barkume M; Anti-Cancer Drug Screening Facility (ACDSF), Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India. Electronic address: madan_barkume@yahoo.co.in.
Sen S; Anti-Cancer Drug Screening Facility (ACDSF), Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India. Electronic address: subratasen23.ss@gmail.com.
Kasinathan NK; Anti-Cancer Drug Screening Facility (ACDSF), Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India. Electronic address: kasinathan.nirmalkumar@gmail.com.
Chaudhari P; Homi Bhabha National Institute (HBNI), Training School Complex, Anushakti Nagar, Mumbai 400085, India; Small Animal Imaging Facility, Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India. Electronic address: pchaudhari@
Mohanty BS; Small Animal Imaging Facility, Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India. Electronic address: bhabani.bmohanty@gmail.com.
Gour J; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India. Electronic address: jeetugour1810@gmail.com.
Sigalapalli DK; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India. Electronic address: dileepsigalapalli@gmail.com.
Ganesh Kumar C; Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi 110025, India. Electronic address: cgkumar5@gmail.com.
Pradhan T; Tumor Immunology & Immunotherapy Group, Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India. Electronic address: truptininadpradhan@gmail.com.
Banerjee M; Homi Bhabha National Institute (HBNI), Training School Complex, Anushakti Nagar, Mumbai 400085, India; Molecular Biology Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085, India. Electronic address: manishab@barc.gov.in.
Kamal A; Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi 110025, India; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Researc

Bioorg Chem ; 105: 104447, 2020 12.

Article em En | MEDLINE | ID: mdl-33207276

Assuntos

Antineoplásicos/síntese química; Benzofenonas/química; Chalcona/síntese química; Indóis/química; Neoplasias Bucais/tratamento farmacológico; Moduladores de Tubulina/síntese química; Animais; Antineoplásicos/farmacologia; Domínio Catalítico; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Chalcona/farmacologia; Colchicina/química; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Masculino; Camundongos; Simulação de Acoplamento Molecular; Estrutura Molecular; Neoplasias Bucais/diagnóstico por imagem; Neoplasias Experimentais; Tomografia por Emissão de Pósitrons; Ligação Proteica; Tubulina (Proteína)/metabolismo; Moduladores de Tubulina/farmacologia

Palavras-chave

(18)F-fluorodeoxyglucose uptake; Anti-cancer efficacy; Cancer stem- like cells; Glucose metabolism; Immunofluorescence; In silico analysis; In vitro cell cytotoxicity; Laser confocal microscopy; Molecular docking; Multi-target metabolic inhibitor; Oral cancer xenograft model; PET-CT imaging; Phenstatin based indole-linked chalcones; Spheroid assay; Surface Plasmon Resonance; Transmission electron microscopy; Tubulin polymerization inhibition

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzofenonas / Neoplasias Bucais / Chalcona / Moduladores de Tubulina / Indóis / Antineoplásicos Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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