Your browser doesn't support javascript.
loading
Early childhood infections, antistreptococcal and basal ganglia antibodies in adult ADHD: a preliminary study.
Oliva, Francesco; di Girolamo, Giulia; Malandrone, Francesca; Iaia, Noemi; Biasi, Fiorella; Maina, Giuseppe.
Afiliação
  • Oliva F; Department of Clinical and Biological Science, University of Turin, Orbassano (TO), Italy. francesco.oliva@unito.it.
  • di Girolamo G; Department of Neurosciences "Rita Levi Montalcini", University of Turin, Turin, Italy.
  • Malandrone F; Department of Clinical and Biological Science, University of Turin, Orbassano (TO), Italy.
  • Iaia N; Department of Clinical and Biological Science, University of Turin, Orbassano (TO), Italy.
  • Biasi F; Department of Clinical and Biological Science, University of Turin, Orbassano (TO), Italy.
  • Maina G; Department of Neurosciences "Rita Levi Montalcini", University of Turin, Turin, Italy.
BMC Psychiatry ; 20(1): 542, 2020 11 18.
Article em En | MEDLINE | ID: mdl-33208138
BACKGROUND: To explore the relationship between adult Attention Deficit/ Hyperactivity Disorder (ADHD), antistreptococcal titers, ABGA, and recurrent infections during early childhood. METHOD: Childhood history of recurrent infections and a blood sample were collected in a sample of DSM-IV adult outpatients with ADHD. The anti-streptolysin O (ASO), anti-deoxyribonuclease B (anti-DNase B), and anti-basal ganglia antibodies (ABGA) titers were determined in patient plasma by enzyme-linked immunosorbent assay (ELISA). Titers positivity was evaluated following manufacturer's specifications. Absolute titers were also collected as continuous variables. RESULTS: Fourteen out of 22 (63.6%) have had recurrent infections in childhood (i.e., seven, 31.8%, have had tonsillitis or adenoiditis and seven, 31.8%, have had any other infections). Eighteen patients (81.9%) were positive for anti-DNase B, five (22.7%) for ASO, and 4 (18.2%) were positive for both of them. Five participants (22.7%) were ABGA positive, whereas only two (9.1%) were positive for all three antibodies. CONCLUSIONS: patients with ADHD might be more prone to infections during childhood and subclinical streptococcal infections during adulthood. Moreover, they seem to have an increased risk for basal ganglia autoimmunity in adulthood. Both infections and the ensuing acquired autoimmunity could influence the neurodevelopmental process, by contributing, at least in part, to the ADHD pathogenesis.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno do Deficit de Atenção com Hiperatividade / Infecções Estreptocócicas Limite: Adult / Child / Child, preschool / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno do Deficit de Atenção com Hiperatividade / Infecções Estreptocócicas Limite: Adult / Child / Child, preschool / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article