Immunity and amyloid beta, total tau and neurofilament light chain: Findings from a community-based cohort study.
Alzheimers Dement
; 17(3): 446-456, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-33215849
ABSTRACT
INTRODUCTION:
We investigated how components of immunity relate to biomarkers of Alzheimer's disease (AD) in plasma and explored the influence of AD genetic risk factors in the population-based Rotterdam Study.METHODS:
In 7397 persons, we calculated the granulocyte-to-lymphocyte ratio (GLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). In 3615 of these persons, plasma amyloid-beta (Aß)42 and Aß40 were measured. Next, we constructed an overall genetic risk score (GRS) based on genome-wide significant variants, both including and excluding APOE ε4.RESULTS:
All innate immunity phenotypes were related to higher Aß, most strongly with a doubling in GLR leading to a 1.9% higher Aß42 (95% confidence interval [95% CI] 0.4 to 3.3%) and 3.2% higher Aß40 (95% CI 2.0 to 4.3%). Higher AD GRS including APOE ε4 was associated with higher immunity markers.DISCUSSION:
Higher levels of immunity markers were associated with higher Aß in plasma. Participants with a higher genetic predisposition to AD had higher immunity markers, where these effects were mainly driven by APOE ε4.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
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Peptídeos beta-Amiloides
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Proteínas de Neurofilamentos
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Proteínas tau
/
Doença de Alzheimer
/
Imunidade
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article