Physicochemical characteristics and in vitro permeation of loratadine solid lipid nanoparticles for transdermal delivery.
Ther Deliv
; 11(11): 685-700, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-33225838
ABSTRACT
Aim:
To prepare loratadine-loaded solid lipid nanoparticles (SLNs) using a modified two-step ultrasound-assisted phase inversion temperature (PIT) process. Results/methodology:
Loratadine was dissolved in beeswax and Tween 80 was dissolved in water. The two phases were mixed together to prepare a water-in-oil emulsion preconcentrate (w/o) at a PIT of 85°C, followed by gradual water addition at 25°C to trigger nanoparticles formation (o/w). Kinetic stability was investigated. No change in the size was observed within 6 months. Fourier-transform infrared spectroscopy demonstrated stability of the emulsions via molecular structure of water at the interface of the o/w nanoemulsions. SLNs enhanced the in vitro skin permeation of loratadine.Conclusion:
Stable SLNs were successfully prepared by ultrasound-assisted PIT.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Loratadina
/
Nanopartículas
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article