Absence of mgrB Alleviates Negative Growth Effects of Colistin Resistance in Enterobacter cloacae.
Antibiotics (Basel)
; 9(11)2020 Nov 19.
Article
em En
| MEDLINE
| ID: mdl-33227907
ABSTRACT
Colistin is an important last-line antibiotic to treat highly resistant Enterobacter infections. Resistance to colistin has emerged among clinical isolates but has been associated with a significant growth defect. Here, we describe a clinical Enterobacter isolate with a deletion of mgrB, a regulator of colistin resistance, leading to high-level resistance in the absence of a growth defect. The identification of a path to resistance unrestrained by growth defects suggests colistin resistance could become more common in Enterobacter.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article