Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles.

Gu, Jinge; Liu, Zhenying; Zhang, Shengnan; Li, Yichen; Xia, Wencheng; Wang, Chen; Xiang, Huaijiang; Liu, Zhijun; Tan, Li; Fang, Yanshan; Liu, Cong; Li, Dan

Gu, Jinge; Liu, Zhenying; Zhang, Shengnan; Li, Yichen; Xia, Wencheng; Wang, Chen; Xiang, Huaijiang; Liu, Zhijun; Tan, Li; Fang, Yanshan; Liu, Cong; Li, Dan.

Afiliação

Gu J; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Liu Z; University of the Chinese Academy of Sciences, Shijingshan District, Beijing 100049, China.
Zhang S; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Li Y; University of the Chinese Academy of Sciences, Shijingshan District, Beijing 100049, China.
Xia W; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Wang C; University of the Chinese Academy of Sciences, Shijingshan District, Beijing 100049, China.
Xiang H; Bio-X-Renji Hospital Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Liu Z; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Tan L; University of the Chinese Academy of Sciences, Shijingshan District, Beijing 100049, China.
Fang Y; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.
Liu C; University of the Chinese Academy of Sciences, Shijingshan District, Beijing 100049, China.
Li D; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China.

Proc Natl Acad Sci U S A ; 117(49): 31123-31133, 2020 12 08.

Article em En | MEDLINE | ID: mdl-33229560

Assuntos

Proteínas de Choque Térmico HSP40/genética; Chaperonas Moleculares/genética; Membrana Celular/genética; Humanos; Membranas; Organelas/genética; Ligação Proteica/genética; Proteína FUS de Ligação a RNA/genética; Ubiquitina/genética

Palavras-chave

ALS; FUS; Hsp40; LLPS; stress granule

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Chaperonas Moleculares / Proteínas de Choque Térmico HSP40 Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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