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Multi-organ comparison of flow-based arterial spin labeling techniques: Spatially non-selective labeling for cerebral and renal perfusion imaging.
Franklin, Suzanne L; Bones, Isabell K; Harteveld, Anita A; Hirschler, Lydiane; van Stralen, Marijn; Qin, Qin; de Boer, Anneloes; Hoogduin, Johannes M; Bos, Clemens; van Osch, Matthias J P; Schmid, Sophie.
Afiliação
  • Franklin SL; C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Bones IK; Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Harteveld AA; Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands.
  • Hirschler L; Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands.
  • van Stralen M; Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Qin Q; C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
  • de Boer A; Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands.
  • Hoogduin JM; Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Bos C; The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • van Osch MJP; Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Schmid S; Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands.
Magn Reson Med ; 85(5): 2580-2594, 2021 05.
Article em En | MEDLINE | ID: mdl-33251644
PURPOSE: Flow-based arterial spin labeling (ASL) techniques provide a transit-time insensitive alternative to the more conventional spatially selective ASL techniques. However, it is not clear which flow-based ASL technique performs best and also, how these techniques perform outside the brain (taking into account eg, flow-dynamics, field-inhomogeneity, and organ motion). In the current study we aimed to compare 4 flow-based ASL techniques (ie, velocity selective ASL, acceleration selective ASL, multiple velocity selective saturation ASL, and velocity selective inversion prepared ASL [VSI-ASL]) to the current spatially selective reference techniques in brain (ie, pseudo-continuous ASL [pCASL]) and kidney (ie, pCASL and flow alternating inversion recovery [FAIR]). METHODS: Brain (n = 5) and kidney (n = 6) scans were performed in healthy subjects at 3T. Perfusion-weighted signal (PWS) maps were generated and ASL techniques were compared based on temporal SNR (tSNR), sensitivity to perfusion changes using a visual stimulus (brain) and robustness to respiratory motion by comparing scans acquired in paced-breathing and free-breathing (kidney). RESULTS: In brain, all flow-based ASL techniques showed similar tSNR as pCASL, but only VSI-ASL showed similar sensitivity to perfusion changes. In kidney, all flow-based ASL techniques had comparable tSNR, although all lower than FAIR. In addition, VSI-ASL showed a sensitivity to B1 -inhomogeneity. All ASL techniques were relatively robust to respiratory motion. CONCLUSION: In both brain and kidney, flow-based ASL techniques provide a planning-free and transit-time insensitive alternative to spatially selective ASL techniques. VSI-ASL shows the most potential overall, showing similar performance as the golden standard pCASL in brain. However, in kidney, a reduction of B1 -sensitivity of VSI-ASL is necessary to match the performance of FAIR.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Algoritmos / Imagem de Perfusão Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Algoritmos / Imagem de Perfusão Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article