Deciphering the Role of Filamin B Calponin-Homology Domain in Causing the Larsen Syndrome, Boomerang Dysplasia, and Atelosteogenesis Type I Spectrum Disorders via a Computational Approach.

S, Udhaya Kumar; Sankar, Srivarshini; Younes, Salma; D, Thirumal Kumar; Ahmad, Muneera Naseer; Okashah, Sarah Samer; Kamaraj, Balu; Al-Subaie, Abeer Mohammed; C, George Priya Doss; Zayed, Hatem

S, Udhaya Kumar; Sankar, Srivarshini; Younes, Salma; D, Thirumal Kumar; Ahmad, Muneera Naseer; Okashah, Sarah Samer; Kamaraj, Balu; Al-Subaie, Abeer Mohammed; C, George Priya Doss; Zayed, Hatem.

Afiliação

S UK; School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, India.
Sankar S; School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, India.
Younes S; Department of Biomedical Sciences, College of Health and Sciences, Qatar University, QU Health, Doha 2713, Qatar.
D TK; School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, India.
Ahmad MN; Department of Biomedical Sciences, College of Health and Sciences, Qatar University, QU Health, Doha 2713, Qatar.
Okashah SS; Department of Biomedical Sciences, College of Health and Sciences, Qatar University, QU Health, Doha 2713, Qatar.
Kamaraj B; Department of Neuroscience Technology, College of Applied Medical Sciences in Jubail, Imam Abdulrahman Bin Faisal University, Jubail 35816, Saudi Arabia.
Al-Subaie AM; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
C GPD; School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu 632014, India.
Zayed H; Department of Biomedical Sciences, College of Health and Sciences, Qatar University, QU Health, Doha 2713, Qatar.

Molecules ; 25(23)2020 Nov 26.

Article em En | MEDLINE | ID: mdl-33255942

Assuntos

Proteínas de Ligação ao Cálcio/química; Filaminas/química; Proteínas dos Microfilamentos/química; Modelos Moleculares; Domínios Proteicos; Fenômenos Químicos; Nanismo/etiologia; Evolução Molecular; Fácies; Filaminas/genética; Filaminas/metabolismo; Variação Genética; Humanos; Simulação de Dinâmica Molecular; Mutação; Osteocondrodisplasias/etiologia; Polimorfismo de Nucleotídeo Único; Conformação Proteica; Solventes/química; Relação Estrutura-Atividade; Calponinas

Palavras-chave

CH2 domain; FLNB; Larsen syndrome; atelosteogenesis type I; boomerang dysplasia; molecular dynamics simulation (MDS)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ligação ao Cálcio / Modelos Moleculares / Filaminas / Domínios Proteicos / Proteínas dos Microfilamentos Tipo de estudo: Etiology_studies / Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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