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Amplification-free long-read sequencing reveals unforeseen CRISPR-Cas9 off-target activity.
Höijer, Ida; Johansson, Josefin; Gudmundsson, Sanna; Chin, Chen-Shan; Bunikis, Ignas; Häggqvist, Susana; Emmanouilidou, Anastasia; Wilbe, Maria; den Hoed, Marcel; Bondeson, Marie-Louise; Feuk, Lars; Gyllensten, Ulf; Ameur, Adam.
Afiliação
  • Höijer I; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. ida.hoijer@igp.uu.se.
  • Johansson J; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Gudmundsson S; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Chin CS; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
  • Bunikis I; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.
  • Häggqvist S; Foundation for Biological Data Science, Belmont, CA, USA.
  • Emmanouilidou A; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Wilbe M; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • den Hoed M; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Bondeson ML; The Beijer laboratory and Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Feuk L; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Gyllensten U; Science for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
  • Ameur A; The Beijer laboratory and Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Genome Biol ; 21(1): 290, 2020 12 01.
Article em En | MEDLINE | ID: mdl-33261648
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sequência de Bases / Biologia Computacional / Sistemas CRISPR-Cas / Edição de Genes Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sequência de Bases / Biologia Computacional / Sistemas CRISPR-Cas / Edição de Genes Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article