miR-15a-5p and miR-21-5p contribute to chemoresistance in cytogenetically normal acute myeloid leukaemia by targeting PDCD4, ARL2 and BTG2.

Vandewalle, Virginie; Essaghir, Ahmed; Bollaert, Emeline; Lenglez, Sandrine; Graux, Carlos; Schoemans, Hélène; Saussoy, Pascale; Michaux, Lucienne; Valk, Peter J M; Demoulin, Jean-Baptiste; Havelange, Violaine

Vandewalle, Virginie; Essaghir, Ahmed; Bollaert, Emeline; Lenglez, Sandrine; Graux, Carlos; Schoemans, Hélène; Saussoy, Pascale; Michaux, Lucienne; Valk, Peter J M; Demoulin, Jean-Baptiste; Havelange, Violaine.

Afiliação

Vandewalle V; Department of Hematology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Essaghir A; Experimental Medicine Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
Bollaert E; Experimental Medicine Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
Lenglez S; Experimental Medicine Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
Graux C; Experimental Medicine Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
Schoemans H; Department of Hematology, CHU UCL Namur (Godinne site), Yvoir, Belgium.
Saussoy P; Department of Hematology, University Hospitals Leuven and KU Leuven, Leuven, Belgium.
Michaux L; Laboratory of Hematology, Cliniques Universitaires Saint Luc, Brussels, Belgium.
Valk PJM; Center for Human Genetics, University Hospitals Leuven and KU Leuven, Leuven, Belgium.
Demoulin JB; Department of Hematology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Havelange V; Experimental Medicine Unit, de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.

J Cell Mol Med ; 25(1): 575-585, 2021 01.

Article em En | MEDLINE | ID: mdl-33270982

Assuntos

Leucemia Mieloide Aguda/metabolismo; MicroRNAs/metabolismo; Apoptose/efeitos dos fármacos; Apoptose/genética; Apoptose/fisiologia; Western Blotting; Linhagem Celular Tumoral; Citarabina/farmacologia; Daunorrubicina/farmacologia; Resistencia a Medicamentos Antineoplásicos/genética; Resistencia a Medicamentos Antineoplásicos/fisiologia; Humanos; Leucemia Mieloide Aguda/genética; MicroRNAs/genética; Mutação/genética; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Nucleofosmina; Análise de Componente Principal; RNA Interferente Pequeno/genética; RNA Interferente Pequeno/metabolismo

Palavras-chave

acute myeloid leukaemia; apoptosis; chemoresistance; microRNAs; target genes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / MicroRNAs Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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