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The surface lipoproteins of gram-negative bacteria: Protectors and foragers in harsh environments.
Cole, Gregory B; Bateman, Thomas J; Moraes, Trevor F.
Afiliação
  • Cole GB; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
  • Bateman TJ; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
  • Moraes TF; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada. Electronic address: trevor.moraes@utoronto.ca.
J Biol Chem ; 296: 100147, 2021.
Article em En | MEDLINE | ID: mdl-33277359
ABSTRACT
Gram-negative pathogens are enveloped by an outer membrane that serves as a double-edged sword On the one hand, it provides a layer of protection for the bacterium from environmental insults, including other bacteria and the host immune system. On the other hand, it restricts movement of vital nutrients into the cell and provides a plethora of antigens that can be detected by host immune systems. One strategy used to overcome these limitations is the decoration of the outer surface of gram-negative bacteria with proteins tethered to the outer membrane through a lipid anchor. These surface lipoproteins (SLPs) fulfill critical roles in immune evasion and nutrient acquisition, but as more bacterial genomes are sequenced, we are beginning to discover their prevalence and their different roles and mechanisms and importantly how we can exploit them as antimicrobial targets. This review will focus on representative SLPs that gram-negative bacteria use to overcome host innate immunity, specifically the areas of nutritional immunity and complement system evasion. We elaborate on the structures of some notable SLPs required for binding target molecules in hosts and how this information can be used alongside bioinformatics to understand mechanisms of binding and in the discovery of new SLPs. This information provides a foundation for the development of therapeutics and the design of vaccine antigens.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias Gram-Negativas / Lipoproteínas Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias Gram-Negativas / Lipoproteínas Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article