Association Between Carbon Monoxide Intoxication and Incidence of Ischemic Stroke: A Retrospective Nested Case-Control Study in South Korea.
J Stroke Cerebrovasc Dis
; 30(2): 105496, 2021 Feb.
Article
em En
| MEDLINE
| ID: mdl-33278806
ABSTRACT
OBJECTIVES:
Severe neurological sequelae occur in patients with carbon monoxide (CO) intoxication; however, whether the latter increases the long-term risk of developing ischemic stroke is unclear. We investigated the association between CO intoxication and ischemic stroke using data from the Korean National Health Information Database. MATERIALS ANDMETHODS:
We performed a retrospective, nested case-control study of 27,984 individuals treated for CO intoxication and 27,984 sex- and age-matched controls. Initially, we calculated the overall incidence and hazard ratio (HR) of ischemic stroke using conditional logistic regression. Thereafter, we calculated the incidences and HRs according to covariates and follow-up periods.RESULTS:
The CO intoxication group had a significantly higher risk of developing ischemic stroke than the control group (adjusted HR 2.31, 95% CI [confidence interval]â¯=â¯2.01-2.65). Male sex (adjusted HR 2.73, 95% CIâ¯=â¯2.23-3.34), age <40 (adjusted HR 3.53, 95% CIâ¯=â¯2.15-5.82), low income (adjusted HR 2.55, 95% CIâ¯=â¯1.56-4.15), comorbidities (adjusted HR 2.59, 95% CIâ¯=â¯1.48-4.52), and current smokers (adjusted HR 3.55, 95% CIâ¯=â¯1.67-7.60) had a higher risk of ischemic stroke. The risk of ischemic stroke was highest within 2 years after CO intoxication (adjusted HR 7.47, 95% CIâ¯=â¯2.76-20.26), and even >6 years after, the risk remained significantly higher than in the control group (adjusted HR 1.84, 95% CIâ¯=â¯1.53-2.20).CONCLUSIONS:
CO intoxication and the long-term risk of ischemic stroke are associated.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Intoxicação por Monóxido de Carbono
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AVC Isquêmico
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article