Correlation of L-asp Activity, Anti-L-asp Antibody, Asn and Gln With Adverse Events Especially Anaphylaxis Risks in PEG-asp-Contained Regime Treated Pediatric ALL Patients.

Wu, Juan; Chen, Changcheng; Huang, Shiying; Shen, Shuhong; Chen, Jing; Zhang, Shunguo

Wu, Juan; Chen, Changcheng; Huang, Shiying; Shen, Shuhong; Chen, Jing; Zhang, Shunguo.

Afiliação

Wu J; Department of Pharmacy, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Chen C; Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Huang S; Department of Pharmacy, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Shen S; Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Chen J; Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Zhang S; Department of Pharmacy, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Technol Cancer Res Treat ; 19: 1533033820980113, 2020.

Article em En | MEDLINE | ID: mdl-33287663

Assuntos

Anafilaxia/sangue; Anafilaxia/etiologia; Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos; Asparaginase/sangue; Hipersensibilidade a Drogas/sangue; Hipersensibilidade a Drogas/etiologia; Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações; Adolescente; Fatores Etários; Anafilaxia/diagnóstico; Antineoplásicos Imunológicos/administração & dosagem; Antineoplásicos Imunológicos/efeitos adversos; Antineoplásicos Imunológicos/uso terapêutico; Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico; Asparaginase/antagonistas & inibidores; Asparagina/sangue; Biomarcadores/sangue; Criança; Pré-Escolar; Hipersensibilidade a Drogas/diagnóstico; Feminino; Glutamina/sangue; Humanos; Lactente; Masculino; Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico; Prognóstico; Curva ROC

Palavras-chave

L-asparaginase activity; adverse events; anaphylaxis; pediatric acute lymphoblastic leukemia; polyethylene glycol-conjugated L-asparaginase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asparaginase / Protocolos de Quimioterapia Combinada Antineoplásica / Hipersensibilidade a Drogas / Leucemia-Linfoma Linfoblástico de Células Precursoras / Anafilaxia Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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